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Thread: Anyone know about Triptorelin?

  1. #1
    Founding Member Mini-G's Avatar
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    Anyone know about Triptorelin?

    Title says it all. I heard its a wicked peptide that helped start this guys balls after 13 years of TRT.

  2. #2
    VET warmouth's Avatar
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    You and those usless balls, lol! Ive never hear anything of it before. Have you found out enought to share the basics?

  3. #3
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by warmouth View Post
    You and those usless balls, lol! Ive never hear anything of it before. Have you found out enought to share the basics?
    Not yet. All I found so far is it flares natural Testosterone. Whatever the fuck that means. I've been busy all day and how I'm at the gym and will be busy all night. Will research ad share when I'm free

  4. #4
    Steroidal.com Writer/Mod Dan C's Avatar
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    I know vaguely about it. I might begin research into it to see how it might possibly assist recovery greatly during PCT.

    Basically what it is, is a synthetic analogue of GnRH (Gonadotropin Releasing Hormone). Basically, this is how your HPTA works

    Hypothalamus releases GnRH - this tells the pituitary to release gonadotropins (LH and FSH) - those gonadotropins tell the testes to produce Testosterone. For more detailed information n the HPTA, see my article on PCT here Post Cycle Therapy | Steroidal.com and scroll down to "The HPTA: How It Works".

    Anyhow, Triptorelin is a GnRH agonist. By acting as such, it stimulates the pituitary gland to pump out LH and FSH. Sounds awesome! BUT (and there is always a big BUT with these things), it is actually used in clinical medial research to REDUCE THE PITUITARY GLAND'S OUTPUT OF GONADOTROPINS and the medical establishment is looking into using it for this purpose in order to treat people who are afflicted with androgen-responsive prostate cancers and such. So now you must be thinking "WTF, how the heck does that work if it acts as GnRH and is supposed to stimulate the pituitary?!". Well, like everything in the endocrine system, the pituitary's response to GnRH operates through the negative feedback loop. So, what the medical application of Triptorelin relies on is the OVER stimulation (or constant stimulation) of the pituitary gland, which will cause a decrease in the secretion of LH and FSH, which results in decreased Testosterone and androgen production. But, if Triptorelin is used in smaller doses and for shorter periods of time, the 'sweet spot' might be hit at the pituitary and it should very well stimulate the pituitary to release gonadotropins, which would undoubtedly be beneficial for recovery during PCT and for people afflicted with hypogonadism. Needless to say, through this action, it will possibly make the use of HCG obsolete!

    The manner by which Triptorelin will hamper gonadotropin release is through the similar manner that HCG will hamper Testosterone production at the testes. Just enough HCG will stimulate the Leydig cells of the testes to secrete Testosterone, right? Well, what about too much HCG (or HCG administration for too long)? That's right, it will actually desensitize the Leydig cells and result in hampered Testosterone production. Same/similar deal here with Triptorelin/GnRH interaction with the pituitary.

    So, this might be the magic bullet for PCT. I will soon be looking into doing much reading of clinical data as well as research to see if it can be applied efficiently and effectively for PCT. I do know that there are people out there who are already doing it. It's just a matter of gathering data and people's experiences at this point, and constructing a protocol.

  5. #5
    Founding Member Mini-G's Avatar
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    Jesus... I would definitely like to look into it more and find some human trials (or personal experiences)... I mean if this can really do what people say it does (replace various Things in PCT and if manipulated right-restart the TESTICLES) then... Hell I found my golden ticket. But I'm definitely not going to mess around with it in hopes that it works considering it MAY have the opposite effect, like you said.. I don't know.. I wanna wait for more research to be done or what have you.

  6. #6
    VET warmouth's Avatar
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    Whoa! Hey mini....... Who can you count on? Anything else? That does seem very beneficial to PCT.

  7. #7
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by warmouth View Post
    Whoa! Hey mini....... Who can you count on? Anything else? That does seem very beneficial to PCT.
    Who can I count on?....


    Dan? Hahaha

  8. #8
    Steroidal.com Writer/Mod Dan C's Avatar
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    Quote Originally Posted by Mini-G View Post
    Jesus... I would definitely like to look into it more and find some human trials (or personal experiences)... I mean if this can really do what people say it does (replace various Things in PCT and if manipulated right-restart the TESTICLES) then... Hell I found my golden ticket. But I'm definitely not going to mess around with it in hopes that it works considering it MAY have the opposite effect, like you said.. I don't know.. I wanna wait for more research to be done or what have you.
    The opposite effect from what we ideally want is just a matter of dose and/or duration. I've already been collecting data and studies, and from what I've seen so far, this stuff looks like it really is an incredible compound for both PCT as well as recovery of HRT patients. If you're someone who has hypogonadism and nothing else has worked in restoring it (HCG, SERMs, AIs, etc.) then this just might do it for you. I've already come across some anecdotal reports of people who have struggled with hypogonadism for years who have remedied it by taking one (yes, ONE), 1 shot of Triptorelin. I have yet to come across any clinical studies that investigate the use of Triptorelin for restoring Testosterone production, though. This is likely because it hasn't occurred to anyone in the medical industry to use it for that purpose (or maybe they don't WANT to look into it because perhaps they make more money off of selling TRT prescriptions rather than curing someone of their hypogonadism... after all, can't make money off a cured person, right?).

    Either way... I've decided to go head-long into doing some heavy reading up and research on it. It is VERY VERY VERY VERY VERY VERY VERY cheap too, especially considering what would be the dose required to stimulate Testosterone secretion...

  9. #9
    Founding Member Mini-G's Avatar
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    I can definitely always count on you Dan!! Dive in and keep me updated here on your findings!! Maybe ill be the guinae pig and try it out haha

  10. #10
    Steroidal.com Writer/Mod Dan C's Avatar
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    I say go for it. Get bloodwork before and after you use it. Then get bloodwork done several months later, making sure you haven't touched or used a single thing during those several months because you really want to try and create a controlled environment as best as possible. That means no cycles, no SERMs, no peptides, no IGF-1, NOTHING. You're someone who has hypogonadism and is a pretty bad case already, right? You'd be the perfect candidate to try it out.

    I just need to do some more research and find out what the proper effective dose of this stuff is for the purpose of stimulating the pituitary to release gonadotropins.

  11. #11
    VET warmouth's Avatar
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    This stuff sounds amazing!

  12. #12
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Dan C View Post
    I say go for it. Get bloodwork before and after you use it. Then get bloodwork done several months later, making sure you haven't touched or used a single thing during those several months because you really want to try and create a controlled environment as best as possible. That means no cycles, no SERMs, no peptides, no IGF-1, NOTHING. You're someone who has hypogonadism and is a pretty bad case already, right? You'd be the perfect candidate to try it out.
    I just need to do some more research and find out what the proper effective dose of this stuff is for the purpose of stimulating the pituitary to release gonadotropins.
    Ugh.... That sounds horrible. Couple months???? Ill like... Never survive unless it literally fixes my balls in a day.

  13. #13
    Steroidal.com Writer/Mod Dan C's Avatar
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    Well, here's the thing with Triptorelin (or any GnRH agonist)... the chemical castration effect of it (if you used too high of a dose) doesn't actually happen until 2 - 3 weeks after administration! GnRH agonists do not quickly dissociate from the GnRH receptor. This means they actually remain bound to the receptor for far longer than endogenous GnRH does, and constantly stimulate the pituitary in this way. As a result, there is an initial increase in FSH and LH secretion (commonly referred to as the "flare effect"). After this, according to the clinical data I've seen (and also from anecdotal evidence such as people's logs and stuff), on average it's about 10 days when the hypogonadism kicks in due to the receptor downregulation on the pituitary gland from the GnRH agonist, and that's the chemical castration effect happening.

    So basically... you need to be VERY careful with this stuff. Yes, it seems like an ace-in-the-hole for HPTA recovery, but it also looks like a big giant double-edged sword (that is really sharp). Actually, it's more like a Darth Maul lightsaber. I saw one log where one hypogonadal man was administered 200mcg by his doctor. Person felt like a million bucks in the few days following administration. By day 8, he felt like shit, total libido crash, no energy, just bad all around. Other logs describe people using 100mcg successfully without issue (for the most part). Some seem to be iffy with that dose. So, you know what I say when it comes to this stuff?

    50mcg.

    If this stuff is really as potent and as strong as it seems to be, I say use the smallest effective dose. Triptorelin seems like serious stuff that can make you just as fast as it can break you. I bet a single 50mcg shot taken at the end of a cycle, after all AAS is totally clear from the body, followed by a low dose of Nolvadex for the rest of PCT just to carry things along should be enough to ensure total recovery. No need for HCG, no need for Clomid (Clomid is bullshit on a stick to begin with and I never recommend it anyways). A single shot of Triptorelin in that manner should exhibit a strong enough effect on the pituitary that completely normal HPTA function should be restored within days (as opposed to weeks with a standard PCT). That is why I say follow it with a L O W dose of Nolvadex only to just carry things along.

    Triptorelin is a synthetic decapeptide agonist analog of gonadotropin releasing hormone (GnRH). Comparative in vitro studies showed that triptorelin was 100-fold more active than native GnRH in stimulating luteinizing hormone release from monolayers of dispersed rat pituitary cells in culture and 20-fold more active than native GnRH in displacing 125I-GnRH from pituitary receptor sites.

    In animal studies, triptorelin pamoate was found to have 13–fold higher luteinizing hormone-releasing activity and 21-fold higher follicle-stimulating hormone-releasing activity compared to the native GnRH.
    Source: Trelstar (Triptorelin Pamoate for Injectable Suspension) Drug Information: Clinical Pharmacology - Prescribing Information at RxList

    I just want to make sure: do you (and anyone/everyone else reading this) realize how potent this stuff is?

  14. #14
    Founding Member Mini-G's Avatar
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    Dan.... It's potent enough to castrate a man without actually having to remove the balls. Yeah.... This shits serious

  15. #15
    Founding Member Mini-G's Avatar
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    It's crazy... And crazy scary. Considering having some nut function vs. zero nut function... Lol. One mess up and ya SCREWED. But what if you dose for too high or too long and essentially ruin your balls to point zero.... Wait a few weeks and then dose lower and restart them.???

  16. #16
    Steroidal.com Writer/Mod Dan C's Avatar
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    Apparently the chemical castration is not permanent, but it does take some time to restore function. How long? I don't know, i'll have to dig deeper into studies to find that out. But fact of the matter is that you literally need a single shot of this stuff and that's it, and you should never exceed 5 shots per year of it for HPTA recovery during PCT. Considering the highest number of cycles per year you can squeeze in would be 3, I think it would be fine. But it just goes to show you that ONE single shot at the beginning of PCT is all that is required.

    It's kind of funny considering you'd buy a 2mg bottle of it, reconstitute it, and only use 1/20th of the thing and that's it lol.

    Oh and your idea of waiting a few weeks after the castration and trying to take a lower dose to restart the HPTA won't work. The castration effect is the result of the GnRH receptors on the pituitary being severely down regulated by Triptorelin. Taking a lower dose of Triptorelin several weeks later after the castration effect would do nothing because the receptors are done for. Endogenous GnRH can't bind to those receptors now. How long it takes for these receptors to up-regulate again, I have no idea. If you end up chemically castrating yourself, your only option to continue endogenous Testosterone production while the receptors recover is to use HCG on a regular basis.

  17. #17
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Dan C View Post
    Apparently the chemical castration is not permanent, but it does take some time to restore function. How long? I don't know, i'll have to dig deeper into studies to find that out. But fact of the matter is that you literally need a single shot of this stuff and that's it, and you should never exceed 5 shots per year of it for HPTA recovery during PCT. Considering the highest number of cycles per year you can squeeze in would be 3, I think it would be fine. But it just goes to show you that ONE single shot at the beginning of PCT is all that is required.

    It's kind of funny considering you'd buy a 2mg bottle of it, reconstitute it, and only use 1/20th of the thing and that's it lol.

    Oh and your idea of waiting a few weeks after the castration and trying to take a lower dose to restart the HPTA won't work. The castration effect is the result of the GnRH receptors on the pituitary being severely down regulated by Triptorelin. Taking a lower dose of Triptorelin several weeks later after the castration effect would do nothing because the receptors are done for. Endogenous GnRH can't bind to those receptors now. How long it takes for these receptors to up-regulate again, I have no idea. If you end up chemically castrating yourself, your only option to continue endogenous Testosterone production while the receptors recover is to use HCG on a regular basis.
    It seems like a nice thing to do. I like it. I may try it.

  18. #18
    Founding Member Fast's Avatar
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    I have used 100mg of this stuff. It is very powerfull. However it does not and will not replace a standard PCT. Dan knows the whole story.

    I would never use this stuff again as it caused a great surge then dropped off after a few month. Im back on Clomid and Nolvadex right now redoing my PCT the right way.
    Last edited by Fast; 04-26-2013 at 04:01 AM.

  19. #19
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Fast View Post
    I have used 100mg of this stuff. It is very powerfull. However it does not and will not replace a standard PCT. Dan knows the whole story.

    I would never use this stuff again as it caused a great surge then dropped off after a few month. Im back on Clomid and Nolvadex right now redoing my PCT the right way.
    mcg*** if you used mg your balls would fall off and beat your dick

  20. #20
    Steroidal.com Writer/Mod Dan C's Avatar
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    Fast is definitely right. That's why I recommend 50mcg instead of 100. If 50mcg isn't doing the job, AND I DOUBT IT WONT DO THE JOB, you can always do another 50mcg a few days later. Hell, i'm even thinking a decent protocol might be to do 10mcg per day for the first 5 days of PCT. THese are the things that need to be investigated!

    But regardless, the more I read about it, the more I realize it is NOT a one-shot magic bullet. It seems like it can be used as a solid kickstart to PCT, and then after the initial shot, you need to carry things along with a low dose of Nolvadex. But Triptorelin does look very promising regardless.

  21. #21
    Founding Member Mini-G's Avatar
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    So.. I decided I'm going to give this a go. After my next blast/cycle/increase in anabolic androgenic steroidal compounds/juice/PED's/hormones.

    Yeah.

  22. #22
    Steroidal.com Writer/Mod Dan C's Avatar
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    Excellent, keep us updated. Follow my suggestion and do 50mcg you can't go wrong doing half the recommended dose with something so potent.
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  23. #23
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Dan C View Post
    Excellent, keep us updated. Follow my suggestion and do 50mcg you can't go wrong doing half the recommended dose with something so potent.
    I heard that before.

    Then my nuts shut down and my blood pressure skyrocketed. Haha it's all good i trust your judgement. I might to 75mcg because i heard 100mcg was a hit ad miss but hit good when it did. So maybe not HALF it but less 25%?

  24. #24
    Steroidal.com Writer/Mod Dan C's Avatar
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    50mcg. Seriously. Think about this also: you're using research grade Triptorelin. I'm not saying it's horribly inaccurately dosed, but you never know... and with something as potent as Triptorelin, I would rather UNDER dose it than accidentally over dose it. I'm confident that 50mcg would be enough to stimulate the pituitary by a considerable amount. Like I said before, you can always do an extra 25 - 50mcg shot a few days later if you feel that the first 50mcg shot didn't do enough. I also even suggested that maybe instead of a single giant shot, one could do very small daily doses instead, such as 10mcg every day for 5 - 10 days. Maybe, just maybe, Triptorelin is causing receptor burnout at the pituitary because every protocol thus far has been high concentration shots at once, and it might have a more favorable effect in stimulating the pituitary at tiny daily doses, rather than burning out the pituitary. Hell, what about 5mcg every day for 10 - 20 days?? That might mimic natural GnRH release more closely? I think i'm on to something.
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  25. #25
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Dan C View Post
    50mcg. Seriously. Think about this also: you're using research grade Triptorelin. I'm not saying it's horribly inaccurately dosed, but you never know... and with something as potent as Triptorelin, I would rather UNDER dose it than accidentally over dose it. I'm confident that 50mcg would be enough to stimulate the pituitary by a considerable amount. Like I said before, you can always do an extra 25 - 50mcg shot a few days later if you feel that the first 50mcg shot didn't do enough. I also even suggested that maybe instead of a single giant shot, one could do very small daily doses instead, such as 10mcg every day for 5 - 10 days. Maybe, just maybe, Triptorelin is causing receptor burnout at the pituitary because every protocol thus far has been high concentration shots at once, and it might have a more favorable effect in stimulating the pituitary at tiny daily doses, rather than burning out the pituitary. Hell, what about 5mcg every day for 10 - 20 days?? That might mimic natural GnRH release more closely? I think i'm on to something.
    Face it you just started typing away at that and had no idea what was come next and realized you formulated a hypothesis

  26. #26
    Founding Member Fast's Avatar
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    The problem I have with it is the castration part, it can literally stop your testicles from working, that is why I am never going to use it again. Clomid 4 life.

  27. #27
    Founding Member Mini-G's Avatar
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    Quote Originally Posted by Fast View Post
    The problem I have with it is the castration part, it can literally stop your testicles from working, that is why I am never going to use it again. Clomid 4 life.
    Well... My balls don't work sooooooo I've nothing to fear! And at such a low dose of 50mcg with so much success with people at 100... I'm sure it'll be fine.

  28. #28
    Founding Member Mini-G's Avatar
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    I'm going to give this a shot. I'm going to stop my TRT for 2-3 weeks than get blood work done. I spend the last 2 hours reading studies and personal trials with many updates and such. One personal trial was interesting too me... His trial want as so:

    Subject is 34 years old 5'11" 252lbs an has never used AAS. Cause of hypogonadism unknown.

    2 years prior to his trial
    Testosterone total - 272 ng/dL

    One day prior to trial
    Testosterone total - 275 ng/dL

    100mcg of triptorelin administered

    Four days post shot
    Testosterone total - 465 ng/dL
    *skeptical because of flare effect Tripto is known for*

    Lab sometime between four days post and 11 days post
    Testosterone total - 469 ng/dL

    2 months (less five days) post shot
    Total Testosterone - 800 ng/dL

    4 months and ten days post shot
    Total Testosterone - 768 ng/dL



    So I mean... This guys 100mcg shot (amongst dieting, extra vitamin D and b12) really changed his life. Considering he was at 270+- total Testosterone for 2+ years... Hell it's worth a go.

  29. #29
    Founding Member Mini-G's Avatar
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    I also saw that chemical castrsation levels were like 2.3 mg administered more than once in a year. I still wouldn't do more than 100mcg though.

  30. #30
    Steroidal.com Writer/Mod Dan C's Avatar
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    Quote Originally Posted by Fast View Post
    The problem I have with it is the castration part, it can literally stop your testicles from working, that is why I am never going to use it again. Clomid 4 life.
    It's related to the dose, because Triptorelin is a GnRH analogue that is 100-fold more potent than endogenous GnRH. High doses will basically overstimulate and fry the receptors on the pituitary gland. A proper dose can be achieved, but it has to be very, very small and that's what i'm trying to figure out.
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