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Thread: GW501506

  1. #1
    Member Bull's Avatar
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    GW501506

    Anyone have experience with this stuff?
    My supplier got it not long ago, and I ordered two bottles ASAP. Looking to see how it affects fat loss. From the few logs I've read, it seems to do well. I'm off-cycle, and will include it along with igf-lr3, cjc (no dac), ghrp-2, mgf, and humulin-r.

    Here's a little read I found on it. Can't find original source any more.

    GW-501516
    (also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

    GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

    It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

    Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.

  2. #2
    Steroidal.com Writer/Mod Dan C's Avatar
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    That stuff is junk. Junk. Junk. JUNK.

    I did an extensive review and research of that stuff way back on another forum I used to be on, and not only did I conclude it to be useless for fat loss, but everyone else who utilized it felt it didn't do a think for fat loss. You will see an overwhelming plethora of people's logs of this stuff explaining how it didn't do much of anything. I will say, however, it is extremely useful for enhancing endurance performance. It is seriously one of the greatest PEDs in the arsenal of an endurance athlete without the risks of dangerously high hemoglobin levels that things like EPO produce. But that's about as good as GW-501516 gets. The fat loss thing is still a mystery to everyone. Despite the research behind it, it didn't seem to do anything in that department for most people. Whether that is due to issues concerning sources and/or the quality of various research chemical companies' GW products, I don't know. We might never know. There were very, very, very, very few people who experienced the so-called DNP-like fat loss on it.
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  3. #3
    Member Bull's Avatar
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    Quote Originally Posted by Dan C View Post
    That stuff is junk. Junk. Junk. JUNK.

    I did an extensive review and research of that stuff way back on another forum I used to be on, and not only did I conclude it to be useless for fat loss, but everyone else who utilized it felt it didn't do a think for fat loss. You will see an overwhelming plethora of people's logs of this stuff explaining how it didn't do much of anything. I will say, however, it is extremely useful for enhancing endurance performance. It is seriously one of the greatest PEDs in the arsenal of an endurance athlete without the risks of dangerously high hemoglobin levels that things like EPO produce. But that's about as good as GW-501516 gets. The fat loss thing is still a mystery to everyone. Despite the research behind it, it didn't seem to do anything in that department for most people. Whether that is due to issues concerning sources and/or the quality of various research chemical companies' GW products, I don't know. We might never know. There were very, very, very, very few people who experienced the so-called DNP-like fat loss on it.
    Damn, that's too bad! Maybe I'll just keep what I ordered for my next contest prep where I'll be doing more cardio.

  4. #4
    Administrator Admin's Avatar
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    Never used it, no.

  5. #5
    Steroidal.com Writer/Mod Dan C's Avatar
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    Quote Originally Posted by Bull View Post
    Damn, that's too bad! Maybe I'll just keep what I ordered for my next contest prep where I'll be doing more cardio.
    I have no idea why the results in terms of fat loss were so inconsistent and relatively nonexistent compared to the information expounded by the clinical studies on it. Could've been related to anything from the quality of the research grade stuff to other ambiguous factors. Give it a shot, see how it goes, but more than likely you will end up with the same conclusions that everyone else did.
    Chief writer for Steroidal.com
    Formerly known as Atomini
    Steroidal.com: the world's largest informational resource on anabolic steroids and all things performance enhancing drug related!
    "Strongest minds are often those whom the noisy world hears least" - William Wordsworth

  6. #6
    Member Bull's Avatar
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    Quote Originally Posted by Dan C View Post
    I have no idea why the results in terms of fat loss were so inconsistent and relatively nonexistent compared to the information expounded by the clinical studies on it. Could've been related to anything from the quality of the research grade stuff to other ambiguous factors. Give it a shot, see how it goes, but more than likely you will end up with the same conclusions that everyone else did.
    Luckily, as per your initial response, I cancelled the order before they could ship and got a refund. Saved me 120$ that I'll be spending on some solid peptides like CJC and GHRP. Thanks for that!

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