Diindolyl Methane (DIM)

[nicco]

Hi. Is Diindolyl Methane (DIM) good for estrogen control and increasing free testosterone? What would be the optimal dosage on a 400 mg/wk testosterone cycle. Is it effecteve for pct?

Thanks

[warmouth]

Nicco! What's up? I havent heard of this but am going to do a little digging.

[nicco]

Hey Warmouth. I got some info off a website- http://www.nutragenics.net/bestbody%...pps.htm
DIM (diindolylmethane) is important to use an estrogen metabolizer and an estrogen-receptor blocker. As mentioned above, right after a steroid cycle ends, one's natural testosterone level is anywhere from low to nonexistent. Estrogen, however, is typically very high. DIM increases the ratio of good to bad estrogen metabolites, resulting in lower bad metabolites, providing a beneficial effect in men (men require some estrogen to be in their system). DIM's effect on estrogen also tells the hypothalamus to produce LH which results in the maintenance or even improvement of natural testosterone levels. Moreover, DIM interferes with the activity of the estrogen receptors - basically blocking them - which raises the testosterone to estrogen ratio. Another action of DIM is that it causes more testosterone to be freed from the sex hormone binding globulin (SHBG) protein. Another benefit of DIM, though not critically important within the discussion of post-cycle supplementation is that it may also reduce the chance of prostate enlargement due to the presence of estrogen. When buying DIM, be sure to get a soluble, time-released one, such as BioResponse's patented DIM150 (also used by Nature's Way). Other forms of DIM are poorly absorbed and, thus, a waste of money.

in addition to the info above, The same website recommends that this or any supplement should not replace but instead be used alongside pharma for PCT. I read that a dose of 200 per day is recommended. anything above 300 could have bad sides. Human trials have been done for cancer specific research:
What Is a DIM Supplement? | Healthy Eating | SF Gate

Cliniical Research

Memorial Sloan-Kettering Cancer Center says that DIM has excellent potential as a therapy to prevent or treat cancer in humans. In a clinical study published in "Nutrition and Cancer," post-menopausal women with a history of breast cancer who consumed a DIM supplement for 30 days had changes in estrogen metabolism consistent with a decreased risk of cancer recurrence, compared to women in a placebo group. In a Phase I clinical trial whose results were published in "The American Journal of Translational Research" in 2010, men with treatment-resistant prostate cancer who consumed DIM had a drop in levels of prostate-specific-antigen, or PSA, a marker of cancer, leading the authors to recommend that DIM be used in additional clinical trials. In addition, as of 2012, the National of Institutes of Health has begun a Phase III clinical trial of DIM as a potential treatment for cervical dysplasia, a precancerous condition.

Please post any good info you come across. Looks like an interesting supp