Originally posted by warmouth
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The heat generation is a function of the drug being used, not the other way around.
This means that the use of T3 is what generates the heat. The heat being generated is not required for T3 to work. T3 generates the heat through an increase of nutrients being utilized by the mitochondria of our body's cells, and when they get metabolized there, the result is heat release. This heat release should be an indication of increased metabolic rate. This is why DNP shoots body temperature into dangerous zones. It's why Clenbuterol increases body temperature, and it's also why T3 does it. There will always be a ceiling limit to how much heat is generated in relation to the dose. If your body temperature goes down to normal ranges while on T3, it might mean something different. The whole process of T3 is extremely complex and quite different from other hormones in the body and other hormones we are commonly used to using.... I really can't describe the whole thing right now, but, there are several factors in how well T3 will work:
- RT3 (Reverse T3)
- Total T3 levels
- Cortisol
Often times if fat burning halts with T3, it is because there is not enough Cortisol in the body to drive T3 into the cells to do its job. You see... T3 requires Cortisol in order to work. Yes, Cortisol is a very necessary hormone! It is not the demon devil hormone it has been made out to be... not anywhere NEAR what people have made it out to be! Eliminating Cortisol through whatever means will result in T3 not doing its job just sitting around in your bloodstream. Cortisol is what could be considered the gatekeeper for T3 to enter a cell and instruct the cell to increase its metabolism. No Cortisol = T3 does not get into a cell to do its job. A big sign that you might have inadequate Cortisol levels while on T3: lethargy and a drop in body temperature back to (or below) normal levels.But I won't get any deeper into detail about this than that. I don't want you starting to freak out thinking you need to micromanage this stuff. You'll end up thinking too much into it, lol.
In general, if T3 isn't doing its job somehow, there are several different reasons as to why that might be, and increasing your dose from 100mcg/day of T3 to 150mcg/day of T3 will do nothing but simply waste more of your stocked up T3.
Oh, and VERY IMPORTANT: If you are going to use T3, stay the sam hell away from L-Carnitine!!! L-Carnitine is, for all intents and purposes, a T3 inactivator. L-Carnitine will COMPLETELY BLOCK T3's job at the cellular level. L-Carnitine is a peripheral antagonist of thyroid hormone action. It inhibits the entry of triiodo thyronine and thyroxine into the cell nuclei. Through a randomized trial, Benvenga et al. showed that 2–4 g of oral L-carnitine per day could reverse hyperthyroid symptoms even in the most serious form of hyperthyroidism: thyroid storm. They suggest that since hyperthyroidism impoverishes the tissue deposits of carnitine, there is a rationale for using L-carnitine at least in certain clinical settings. Incidentally, the fact that carnitine failed to prevent relapses of hyperthyroidism further supports the concept that carnitine action is in the periphery and not in the thyroid gland(1). This is why L-Carnitine is actually used as a medicine for the treatment of hyperthyroidism, because it blocks the activity of T3 at the cellular level without actually reducing the manufacture of T3 in the body.
REFERENCES:
1. "Effects of Carnitine on Thyroid Hormone Action". Benvenga, Salvatore; et al (2004). Ann. N.Y. Acad. Sci. 1033 (1033): 158–167. doi:10.1196/annals.1320.015. PMID 15591013.