Aromasin: Are we under dosing?

[OdinsOtherSon]

Here is an interesting article regarding the use of Aromasin. From my reading, 12.5mg eod is the typical starting point for aromasin for e2 control on cycle. What's interesting is that in this article/study, the participants were NOT on cycle and being dosed at 25 and 50mg ED. Another interesting fact is that Aromasin is touted as blocking up to 85% of estrogen. That study was for women...not men. According to this study it seems quite difficult (in comparison to compounds such as a-dex or letro) to crush your E2. Maybe we should re-evaluate how we administer Aromasin??? Input please!

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

[StanG]

I read a great write up on another forum on this very topic - you are a member there did you read it too ?
The conclusion was that we are in fact underdosing stane. Im not sure if it is ok to copy the article and post it here- if it is I certainly will.
After reading it I was convinced that many are underdosing it for sure.

[Dan C]

Yes, it really is a possibility. In my research, I found that Aromasin also requires 7 days of consistent use before it begins to reach peak blood plasma levels to significantly reduce Estrogen levels. Also, taking it every other day may not be the best idea either but I haven't found any solid information on that. Studies have indeed been conducted on men, and have found Aromasin to reduce Estrogen levels by 38% in some studies, which is still a significant amount of you ask me. Check out the Aromasin profile on the main site (specifically the Aromasin Dosage section) to see the references to those studies.

I think it is the best AI out of all of them, but people just don't know enough about it to use it efficiently/correctly.

[BEAR]

When I first started using Aromasin, I didn't get the desired effect from it at the commonly suggested doses & scheduling.......it took me about 3 weeks of adjusting before I found what works, I landed on 10 mg/ed......

I love Aromasin, but I agree, the commonly suggested doses are insufficient.

[Dan C]

I don't think its so much that the dosages are insufficient as much as people are not realizing the time required for it to really be working. And that means that EOD dosing might be an obsolete recommendation. If Aromasin at 25mg per day takes a full week before it reaches peak optimal blood plasma levels... how long will it be before 12.5mg (not every day but every OTHER day!) will reach optimal levels? I am waging not double the time, but triple. Bear, how long did you say it took before you experienced anything at 10mg/day? 3 weeks? I rest my case.

[StanG]

I don't think its so much that the dosages are insufficient as much as people are not realizing the time required for it to really be working. And that means that EOD dosing might be an obsolete recommendation. If Aromasin at 25mg per day takes a full week before it reaches peak optimal blood plasma levels... how long will it be before 12.5mg (not every day but every OTHER day!) will reach optimal levels? I am waging not double the time, but triple. Bear, how long did you say it took before you experienced anything at 10mg/day? 3 weeks? I rest my case.

It takes that long for other ai's to reach stable blood levels as well. Your position is really on based on active life of compound - not "optimal blood levels". Also in the study the OP reffed they were administered stane long enough to achieve this and yet e2 was still within ref range - not below. This was pointed out in the write up i strongly suspect the OP's post is based off of as well....so I wouldn't rest my case just yet.

[Dan C]

You are correct, I shouldn't have rested my case so quickly. I was going to mention the fact that other aromatase inhibitors suffer from the same issue of the aforementioned 7 day period, but I wanted to focus on Aromasin.

If only we could have more studies performed on the administration of Aromasin on men.

[OdinsOtherSon]

I don't think its so much that the dosages are insufficient as much as people are not realizing the time required for it to really be working. And that means that EOD dosing might be an obsolete recommendation. If Aromasin at 25mg per day takes a full week before it reaches peak optimal blood plasma levels... how long will it be before 12.5mg (not every day but every OTHER day!) will reach optimal levels? I am waging not double the time, but triple. Bear, how long did you say it took before you experienced anything at 10mg/day? 3 weeks? I rest my case.

In the study, two groups were tested...one given 25mg ed the other 50mg ed. The only significant difference was the time in which it took to reach optimal plasma levels. I would tend to think you've nailed the entire issue here Dan. Its how long to arrive at optimal levels at a given dose. My $0.02

[StanG]

In the study, two groups were tested...one given 25mg ed the other 50mg ed. The only significant difference was the time in which it took to reach optimal plasma levels. I would tend to think you've nailed the entire issue here Dan. Its how long to arrive at optimal levels at a given dose. My $0.02

Is it your 2 cents or is this entire thread the 2 cents of the person that wrote the original write up you basically plagiarized in one fell post?

[Admin]

Peak estrodoil suppression occurred around 12 hours, so that means estrogen will begin to climb after 12 hours, thus I suggest 2x day dosing.

AI's are more effective in females mostly due to them not producing anywhere near as much testosterone/aromatase as we do. I've said for a long time the number of 80%+ are almost impossible to obtain in males even with Letro.

Bottom line: Get BW done using various AI's and adjust accordingly.

[OdinsOtherSon]

Is it your 2 cents or is this entire thread the 2 cents of the person that wrote the original write up you basically plagiarized in one fell post?

First and lastly of all, I didn't plagiarize anything, I merely post a link to an article that ANYONE can go out and find and summarized it in my own words. So if all you have for me is is smart ass comments, then get the hell off my thread. Non negotiable.

[warmouth]

People, people! lol.

[StanG]

First and lastly of all, I didn't plagiarize anything, I merely post a link to an article that ANYONE can go out and find and summarized it in my own words. So if all you have for me is is smart ass comments, then get the hell off my thread. Non negotiable.

LOL yeah right .....everything you wrote besides the link (no wait that was in there too)was taken directly from a write up on another forum(and you know it). I hate that. NON NEGOTIABLE Mr Thread Owner .......

[StanG]

Peak estrodoil suppression occurred around 12 hours, so that means estrogen will begin to climb after 12 hours, thus I suggest 2x day dosing.

AI's are more effective in females mostly due to them not producing anywhere near as much testosterone/aromatase as we do. I've said for a long time the number of 80%+ are almost impossible to obtain in males even with Letro.

Bottom line: Get BW done using various AI's and adjust accordingly.

Agreed .....it is the only proper, truly effective way to do it.

[OdinsOtherSon]

LOL yeah right .....everything you wrote besides the link (no wait that was in there too)was taken directly from a write up on another forum(and you know it). I hate that. NON NEGOTIABLE Mr Thread Owner .......

You know what, whatever you think bro. I'm not indulging you anymore.