Originally posted by Dan C
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This is actually very true. This also falls in line with the long-since debunked theory that receptors become "saturated" or "burned out" from AAS and that they need to be cleared/cleaned out with time off. Research has demonstrated time and time again that in the presence of androgens, MORE androgen receptors are indeed created. If you read some of my articles on the main site, I explain this quite clearly. This is one of the reasons why it is believed that experienced athletes respond much better to anabolic steroids than beginners and novices that jump on anabolic steroids as soon as they begin training for the first time. It also stands to reason that more androgens = more receptor sites = more androgens in circulation will be able to bind to more receptors and therefore are actually used instead of floating around the bloodstream doing nothing.
HOWEVER, I will say this: the higher the blood plasma levels of AAS, the greater the secretion of SHBG will be, and in a sense this is one of the manners by which the body will become unable to use more than a certain amount of androgens at any one given time. Granted, there are many AAS that are immune to binding with SHBG, and many will actually prevent SHBG from binding to other androgens being used. But this still needs to be kept in mind, for example, if someone is using 1,000mg+ per week of Testosterone with no SHBG-inhibiting AAS, then there indeed will be an issue whereby most of the Testosterone will become bound and essentially at that point your body will indeed only get to use "X" amount of Testosterone with the bound Testosterone (or any other SHBG-prone AAS) going to waste.
HOWEVER, I will say this: the higher the blood plasma levels of AAS, the greater the secretion of SHBG will be, and in a sense this is one of the manners by which the body will become unable to use more than a certain amount of androgens at any one given time. Granted, there are many AAS that are immune to binding with SHBG, and many will actually prevent SHBG from binding to other androgens being used. But this still needs to be kept in mind, for example, if someone is using 1,000mg+ per week of Testosterone with no SHBG-inhibiting AAS, then there indeed will be an issue whereby most of the Testosterone will become bound and essentially at that point your body will indeed only get to use "X" amount of Testosterone with the bound Testosterone (or any other SHBG-prone AAS) going to waste.
Very interesting.